Analyzeを使った文献の紹介

Analyzeは米国メイヨークリニックで開発された多次元生体画像の表示解析プログラムです。
既に25年以上の実績を持ち各方面で非常に多くの利用実績があります。
ここではAnalyze Direct社が提供している文献リストをご紹介します。

Alzheimer’s Disease Research

  • Basso M, Yang J, Warren L, MacAvoy M, Varma P, Bronen R, et al. Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease. Psychiatry Research: Neuroimaging. 2006; 146: 251-61.
  • Black S, Yu D, Moffat S, Stanchev P, Parker J, Bronskill M. Callosal atrophy correlates with temporal lobe volume and mental status in Alzheimer's disease. The Canadian Journal of Neurological Sciences. 2000; 27: 204-09.
  • Galton C, Gomez-Anson B, Antoun N, Scheltens P, Patterson K, Graves M, et al. Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia. British Medical Journal. 2001; 70: 165.
  • Galton C, Patterson K, Graham K, Lambon-Ralph M, Williams G, Antoun N, et al. Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology. 2001; 57: 216.
  • Head D, Snyder A, Girton L, Morris J, Buckner R. Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease. Cerebral Cortex. 2005; 15: 732.
  • Johnson D, Barrow W, Anderson R, Harsha A, Honea R, Brooks W, et al. Diagnostic Utility of Cerebral White Matter Integrity in Early Alzheimer's Disease. International Journal of Neuroscience. 2010; 120: 544-50.
  • Kohler S, Black S, Sinden M, Szekely C, Kidron D, Parker J, et al. Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer’s disease. Neuropsychologia. 1998; 36: 901-14.
  • Masliah E, Mallory M, Deerinck T, Deteresa R, Lamont S, Miller A, et al. Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease. Journal of Neuropathology & Experimental Neurology. 1993; 52: 619.
  • Okello A, Edison P, Archer H, Turkheimer F, Kennedy J, Bullock R, et al. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology. 2009; 72: 56.
  • Royb C, Gaob F, Blackb S. Topographical patterns of lobar atrophy in frontotemporal dementia and Alzheimer’s disease. Dement Geriatr Cogn Disord. 2006; 21: 364-72.
  • Sheline Y, Wang P, Gado M, Csernansky J, Vannier M. Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences. 1996; 93: 3908.
  • Teipel S, Bayer W, Alexander G, Bokde A, Zebuhr Y, Teichberg D, et al. Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer’s disease in relation to dementia severity: evidence for early neocortical degeneration. Neurobiology of Aging. 2003; 24: 85-94.
  • Yakushev I, Muller M, Lorscheider M, Schermuly I, Weibrich C, Dellani P, et al. Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer's disease. Neuropsychologia. 2010; 48: 1447-53.

Brain Structure Volume Assessment

A large number of investigators have used Analyze for brain structure segmentation and analysis. Analyze has been used for over 20 years in some studies, including those done at the Mayo Foundation where the Analyze software is developed.

  • Abrahams S, Morris R, Polkey C, Jarosz J, Cox T, Graves M, et al. Hippocampal involvement in spatial and working memory: a structural MRI analysis of patients with unilateral mesial temporal lobe sclerosis. Brain and Cognition. 1999; 41: 39-65.
  • Antonova E, Parslow D, Brammer M, Dawson G, Jackson S, Morris R. Age-related neural activity during allocentric spatial memory. Memory. 2009; 17: 125-43.
  • Behrmann M, Avidan G, Gao F, Black S. Structural imaging reveals anatomical alterations in inferotemporal cortex in congenital prosopagnosia. Cerebral Cortex. 2007; 17: 2354.
  • Bigler E, Blatter D, Johnson S, Anderson C, Russo A, Gale S, et al. Traumatic brain injury, alcohol and quantitative neuroimaging: preliminary findings. Brain Injury. 1996; 10: 197-206.
  • Cheutin T, O'Donohue M, Beorchia A, Klein C, Kaplan H, Ploton D. Three-dimensional organization of pKi-67: a comparative fluorescence and electron tomography study using fluoronanogold. Journal of Histochemistry and Cytochemistry. 2003; 51: 1411.
  • Cohen J, Mock J, Nichols T, Zadina J, Corey D, Lemen L, et al. Morphometry of human insular cortex and insular volume reduction in Williams syndrome. Journal of Psychiatric Research. 2010; 44: 81-89.
  • Cowell P, Sluming V, Wilkinson I, Cezayirli E, Romanowski C, Webb J, et al. Effects of sex and age on regional prefrontal brain volume in two human cohorts. European Journal of Neuroscience. 2007; 25: 307-18.
  • Csernansky J, Joshi S, Wang L, Haller J, Gado M, Miller J, et al. Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proceedings of the National Academy of Sciences of the United States of America. 1998; 95: 11406.
  • Dade L, Gao F, Kovacevic N, Roy P, Rockel C, O'Toole C, et al. Semiautomatic brain region extraction: a method of parcellating brain regions from structural magnetic resonance images. Neuroimage. 2004; 22: 1492-502.
  • Davidson P, Anaki D, Ciaramelli E, Cohn M, Kim A, Murphy K, et al. Does lateral parietal cortex support episodic memory? Evidence from focal lesion patients. Neuropsychologia. 2008.
  • Furtado C, Maller J, Fitzgerald P. A magnetic resonance imaging study of the entorhinal cortex in treatment-resistant depression. Psychiatry Research: Neuroimaging. 2008; 163: 133-42.
  • George S, Mufson E, Leurgans S, Shah R, Ferrari C, deToledo-Morrell L. MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobiology of aging. 2009.
  • Goncharova I, Dickerson B, Stoub T, deToledo-Morrell L. MRI of human entorhinal cortex: a reliable protocol for volumetric measurement. Neurobiology of Aging. 2001; 22: 737-45.
  • Grunewald R, Farrow T, Vaughan P, Rittey C, Mundy J. A magnetic resonance study of complicated early childhood convulsion. Journal of Neurology, Neurosurgery & Psychiatry. 2001; 71: 638.
  • Head D, Snyder A, Girton L, Morris J, Buckner R. Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease. Cerebral Cortex. 2005; 15: 732.
  • Hedges D, Allen S, Tate D, Thatcher G, Miller M, Rice S, et al. Reduced hippocampal volume in alcohol and substance naive Vietnam combat veterans with posttraumatic stress disorder. Cognitive and Behavioral Neurology. 2003; 16: 219.
  • Hopkins W, Cantalupo C, Taglialatela J. Handedness is associated with asymmetries in gyrification of the cerebral cortex of chimpanzees. Cerebral Cortex. 2007; 17: 1750.
  • Javadapour A, Malhi G, Ivanovski B, Chen X, Wen W, Sachdev P. Hippocampal Volumes in Adults With Bipolar Disorder. Journal of Neuropsychiatry and Clinical Neurosciences. 2010; 22: 55.
  • John J, Shakeel M, Jain S. Corpus callosal area differences and gender dimorphism in neuroleptic-naive, recent-onset schizophrenia and healthy control subjects. Schizophrenia research. 2008; 103: 11-21.
  • Kosta P, Argyropoulou M, Markoula S, Konitsiotis S. MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease. Journal of neurology. 2006; 253: 26-32.
  • Kumar R, Anstey K, Cherbuin N, Wen W, Sachdev P. Association of type 2 diabetes with depression, brain atrophy, and reduced fine motor speed in a 60-to 64-year-old community sample. American Journal of Geriatric Psych. 2008; 16: 989.
  • Lloyd A, Ferrier I, Barber R, Gholkar A, Young A, O'brien J. Hippocampal volume change in depression: late-and early-onset illness compared. The British Journal of Psychiatry. 2004; 184: 488.
  • Maneru C, Junque C, Salgado-Pineda P, Serra-Grabulosa J, Bartres-Faz D, Ramirez-Ruiz B, et al. Corpus callosum atrophy in adolescents with antecedents of moderate perinatal asphyxia. Brain Injury. 2003; 17: 1003.
  • Martin S, Smith C, Collins H, Schmitt F, Gold B. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiology of aging. 2010; 31: 1099-106.
  • Meisenzahl E, Frodl T, Greiner J, Leinsinger G, Maag K, Heiss D, et al. Corpus callosum size in schizophrenia.a magnetic resonance imaging analysis. European Archives of Psychiatry and Clinical Neuroscience. 1999; 249: 305-12.
  • Parikh N, Lasky R, Garza C, Bonfante-Mejia E, Shankaran S, Tyson J. Volumetric and anatomical MRI for hypoxic.ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments. Journal of Perinatology. 2008; 29: 143-49.
  • Parikh N, Lasky R, Kennedy K, Moya F, Hochhauser L, Romo S, et al. Postnatal dexamethasone therapy and cerebral tissue volumes in extremely low birth weight infants. Pediatrics. 2007; 119: 265.
  • Pavese N, Politis M, Tai Y, Barker R, Tabrizi S, Mason S, et al. Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers. Neurobiology of Disease. 2010; 37: 356-61.
  • Rossell S, Shapleske J, Fukuda R, Woodruff P, Simmons A, David A. Corpus callosum area and functioning in schizophrenic patients with auditory-verbal hallucinations. Schizophrenia Research. 2001; 50: 9-17.
  • Shenkin S, Rivers C, Deary I, Starr J, Wardlaw J. Maximum(prior) brain size, not atrophy, correlates with cognition in community-dwelling older people: a cross-sectional neuroimaging study. BMC geriatrics. 2009; 9: 12.
  • Teipel S, Schapiro M, Alexander G, Krasuski J, Horwitz B, Hoehne C, et al. Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome. American Journal of Psychiatry. 2003; 160: 1870.
  • Weber K, Giannakopoulos P, Delaloye C, de Bilbao F, Moy G, Moussa A, et al. Volumetric MRI changes, cognition and personality traits in old age depression. Journal of affective disorders. 2010; 124: 275-82.
  • Brain structure volume assessment . Mayo Clinic investigators:
  • Jack CR Jr, Petersen RC. Structural imaging approaches to Alzheimer's disease. In: Scinto LFM, Daffner KR, editors. Early diagnosis of Alzheimer's disease. Totowa (New Jersey): Humana Press; 2000. p.127-148.
  • Petersen RC, Jack CR Jr, Xu Y-C, Waring SC, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Boeve BF, Kokmen E. Memory and MRI-based hippocampal volumes in aging and AD. Neurology. 2000;54:581-7.
  • Xu Y, Jack CR Jr, O'Brien PC, Kokmen E, Smith GE, Ivnik RJ, Boeve BF, Tangalos RG, Petersen RC. Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology. 2000;54:1760-7.
  • Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Waring SC, Tangalos EG, Kokmen E. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology.1999;52:1397-1403.
  • Jack CR Jr, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Kokmen E. Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology. 1998;51:993-9.
  • Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E. Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol. 1998;43:303-310.
  • Jack CR Jr, Petersen RC, YC Xu, Waring SC, O'Brien PC, Tangalos EG, Smith GE, Ivnik RJ, Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology. 1997;49:786-794.
  • Trenerry MR, Jack CR Jr, Cascino GD, Sharbrough FW, Ivnik RJ. Gender differences in post-temporal lobectomy verbal memory and relationships between MRI hippocampal volumes and preoperative verbal memory. Epilepsy Research. 1995;20:69-76.
  • Jack CR Jr. MRI-based hippocampal volume measurements in epilepsy. Epilepsia. 1994;35 Suppl 6:21-9.
  • Jack CR Jr, Petersen RC, O'Brien PC, et al. MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology. 1992;42:183-188.
  • Jack CR Jr, Sharbrough FW, Cascino GD, et al. MRI-based hippocampal volumetry: correlation with outcome after temporal lobectomy. Ann Neurology. 1992;31:138-146.
  • Jack CR Jr, Bentley M, Twomey CK, Zinsmeister AR. MR-based volume measurements of the hippocampal formation and anterior temporal lobe: validation studies. Radiology. 1990;176:205-209.
  • Jack CR Jr, Sharbrough FW, Twomey CK, et al. Temporal lobe seizures: lateralization with MR volume measurements of hippocampal formation. Radiology. 1990;175:423-9.
  • Jack CR Jr, Twomey CK, Zinsmeister AR, et al. Anterior temporal lobes and hippocampal formations: normative volumetric measurements for MR images in young adults. Radiology. 1989;172:549-554.

Hippocampal volume measurement techniques - Dr. John Haller

  • Haller JW, Banerjee, A, Christensen GE, Gado M, Joshi S, Miller MI, Sheline Y, Vannier MW, Csernansky JG. 3D hippocampal morphometry by high dimensional transformation of a neuroanatomical atlas. Radiology. 1997;202:504-510.
  • Haller JW, Christensen GE, Joshi S, Newcomer JW, Miller MI, Csernansky JG, and Vannier MW. Hippocampal MR morphometry by pattern matching. Radiology. 1996;199:787-791.
  • Haller JW, Christensen GE, Joshi SC, Gado M, Miller MI, Vannier MW. Precision and accuracy of a high dimensional transformation and segmentation of MR images of the hippocampus. In: Bizais Y, Braillot C, Di Paola R, editors. IPMI: Proceedings of the 14th International Conference on Information Processing in Medical Imaging; 1995; Ile de Berder, France. New York: Springer-Verlag; 1995. p.401-2.
  • Haller JW, Christensen GE, Joshi SC, Miller MI, Vannier MW. Digital Atlas-based Segmentation of the Hippocampus. In: Lemke, Inamura, Jaffe, and Vannier, editors. Computer Assisted Radiology. Berlin: Springer Verlag; 1995. p. 152-7.
  • Haller JW, Christensen GE, Miller MI, Gado M, McKeel D, Csernansky J, Vannier, MW. A comparison of automated and manual segmentation of hippocampus MR images. Proc SPIE 2434, 206-215 (1995).
  • Haller JW, Botteron K, Brunsden B, Sheline Y, Walkup R, Black K, Gado M, Vannier M. Hippocampal MR volumetry. Proc. SPIE 2359, 660-661 (1994).

Diffusion Tensor Imaging Studies

  • Bethune A. A Diffusion Tensor Imaging Investigation of White Matter in Pediatric Multiple Sclerosis Patients. 2009.
  • Fellgiebel A, Keller I, Marin D, Muller M, Schermuly I, Yakushev I, et al. Diagnostic utility of different MRI and MR angiography measures in Fabry disease. Neurology. 2009; 72: 63.
  • Kennedy K, Raz N. Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia. 2009; 47: 916-27.
  • Kennedy K, Raz N. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Research. 2009.
  • Kennedy KM, Rodrigue KM, Land SJ, Raz N. BDNF Val66Met Polymorphism Influences Age Differences in Microstructure of the Corpus Callosum. Front Hum Neurosci. 2009; 3: 19.
  • McKinstry R, Mathur A, Miller J, Ozcan A, Snyder A, Schefft G, et al. Radial organization of developing preterm human cerebral cortex revealed by non-invasive water diffusion anisotropy MRI. Cerebral Cortex. 2002; 12: 1237.
  • Shamy J, Carpenter D, Fong S, Murray E, Tang C, Hof P, et al. Alterations of white matter tracts following neurotoxic hippocampal lesions in macaque monkeys: A diffusion tensor imaging study. Hippocampus. 2010; 20: 906-10.
  • Taylor W, Bae J, MacFall J, Payne M, Provenzale J, Steffens D, et al. Widespread effects of hyperintense lesions on cerebral white matter structure. American Journal of Roentgenology. 2007; 188: 1695.
  • Taylor W, Kuchibhatla M, Payne M, MacFall J, Sheline Y, Krishnan K, et al. Frontal White Matter Anisotropy and Antidepressant Remission in Late-Life Depression. PLoS One. 2008; 3.

Fat Quantification

  • Bae KT, Tao C, Zhu F, Bost JE, Chapman AB, Grantham JJ, et al. MRI-based kidney volume measurements in ADPKD: reliability and effect of gadolinium enhancement. Clinical Journal of the American Society of Nephrology. 2009; 4: 719.
  • Bashir A, Laciny E, Lassa-Claxton S, Yarasheski KE. Magnetic resonance imaging for quantifying regional adipose tissue content in HIV-infected people at risk for developing cardiometabolic syndrome. Journal of the cardiometabolic syndrome. 2008; 3: 115.
  • Gong QY, Phoenix J, Kemp GJ, Garcia Finana M, Frostick SP, Brodie DA, et al. Estimation of body composition in muscular dystrophy by MRI and stereology. Journal of Magnetic Resonance Imaging. 2000; 12: 467-75.
  • Tanoli T, Yue P, Yablonskiy D, Schonfeld G. Fatty liver in familial hypobetalipoproteinemia. Journal of lipid research. 2004; 45: 941.
  • Trivedi R. Multi-sequence in vivo MRI can quantify fibrous cap and lipid core components in human carotid atherosclerotic plaques. European journal of vascular and endovascular surgery. 2004; 28: 207-13.
  • Yarasheski K, Cade W, Overton E, Mondy K, Hubert S, Laciny E, et al. Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity. American Journal of Physiology-Endocrinology And Metabolism. 2011; 300: E243.

Segmentation using Multispectral Classification

  • Achiron A, Barak Y. Cognitive impairment in probable multiple sclerosis. British Medical Journal. 2003; 74: 443.
  • Berry E, Handley J, Fitzgerald A, Merchant W, Boyle R, Zinov'ev N, et al. Multispectral classification techniques for terahertz pulsed imaging: an example in histopathology. Medical engineering & physics. 2004; 26: 423-30.
  • Bigler E, Blatter D, Anderson C, Johnson S, Gale S, Hopkins R, et al. Hippocampal volume in normal aging and traumatic brain injury. American Journal of Neuroradiology. 1997; 18: 11.
  • Bigler E, Blatter D, Johnson S, Anderson C, Russo A, Gale S, et al. Traumatic brain injury, alcohol and quantitative neuroimaging: preliminary findings. Brain Injury. 1996; 10: 197-206.
  • Bigler E, Johnson S, Anderson C, Blatter D, Gale S, Russo A, et al. Traumatic brain injury and memory: the role of hippocampal atrophy. Neuropsychology. 1996; 10: 333-42.
  • Bigler E, Lowry C, Anderson C, Johnson S, Terry J, Steed M. Dementia, quantitative neuroimaging, and apolipoprotein E genotype. American Journal of Neuroradiology. 2000; 21: 1857.
  • Blatter D, Bigler E, Gale S, Johnson S, Anderson C, Burnett B, et al. Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life. American Journal of Neuroradiology. 1995; 16: 241.
  • Hedges D, Allen S, Tate D, Thatcher G, Miller M, Rice S, et al. Reduced hippocampal volume in alcohol and substance naive Vietnam combat veterans with posttraumatic stress disorder. Cognitive and Behavioral Neurology. 2003; 16: 219.
  • Jalan R, Turjanski N, Taylor-Robinson S, Koepp M, Richardson M, Wilson J, et al. Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis. Gut. 2000; 46: 546.
  • Lasky R, Luck M, Parikh N, Laughlin N. The effects of early lead exposure on the brains of adult rhesus monkeys: a volumetric MRI study. Toxicological Sciences. 2005; 85: 963.
  • Plassman B, Welsh-Bohmer K, Bigler E, Johnson S. Apolipoprotein Ee4 allele and hippocampal volume in twins with normal cognition. Neurology. 1997; 48: 985-89.
  • Wilde E, Hunter J, Newsome M, Scheibel R, Bigler E, Johnson J, et al. Frontal and temporal morphometric findings on MRI in children after moderate to severe traumatic brain injury. Journal of Neurotrauma. 2005; 22: 333-44.

Orthopaedics Research

  • Benavides E, Bilgen M, Al-Hafez B, Alrefae T, Wang Y, Spencer P. High-resolution magnetic resonance imaging and diffusion tensor imaging of the porcine temporomandibular joint disc. Dentomaxillofacial Radiology. 2009; 38: 148.
  • Engsberg J, Lenke L, Hollander K, Uhrich M, Commean P, Lee J, et al. Methods to locate center of gravity in scoliosis. Spine. 2003; 28: E483.
  • Malizos K, Siafakas M, Fotiadis D, Karachalios T, Soucacos P. An MRI-based semiautomated volumetric quantification of hip osteonecrosis. Skeletal radiology. 2001; 30: 686-93.
  • Manske S, Liu-Ambrose T, de Bakker P, Liu D, Kontulainen S, Guy P, et al. Femoral neck cortical geometry measured with magnetic resonance imaging is associated with proximal femur strength. Osteoporosis International. 2006; 17: 1539-45.
  • McWalter E, MacIntyre N, Cibere J, Wilson D. A single measure of patellar kinematics is an inadequate surrogate marker for patterns of three-dimensional kinematics in healthy knees. The Knee. 2009.
  • Ong K, Day J, Kurtz S, Field R, Manley M. Role of surgical position on interface stress and initial bone remodeling stimulus around hip resurfacing arthroplasty. The Journal of Arthroplasty. 2009; 24: 1137-42.
  • Patel V, Hall K, Ries M, Lindsey C, Ozhinsky E, Lu Y, et al. Magnetic resonance imaging of patellofemoral kinematics with weight-bearing. The Journal of Bone and Joint Surgery. 2003; 85: 2419.
  • Robertson D, Yuan J, Wang G, Vannier M. Total hip prosthesis metal-artifact suppression using iterative deblurring reconstruction. Journal of Computer Assisted Tomography. 1997; 21: 293.
  • Russell C, Chung T, Oxland T. Creation of a finite element model of the rat cervical spine from magnetic resonance images. Journal of Biomechanics. 2008; 41: S516.

Visualization and Analysis of PET Imaging Data

Analyze has been heavily used by the Nuclear Medicine imaging community for well over 20 years. The largest user community early in the lifetime of Analyze was the PET imaging community, which has continued to be one of the largest groups of users. Analyze has also been used very heavily in SPECT imaging, particularly in imaging of activation regions in the brain during seizures in epilepsy.

The benefit of Analyze for functional brain imaging applications is that it provides the complete, synergistic functionality for the direct visualization of the areas of interest, as well as their interaction with the integrated structural/functional volume for further understanding of the complexity of the activation region, further resectioning of the combined display, and direct quantitative analysis of the functional characteristics as guided by the structural anatomy.

  • Barthel H, Cleij M, Collingridge D, Hutchinson O, Osman S, He Q, et al. 3'-deoxy-3'-[18F] fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography. Cancer research. 2003; 63: 3791.
  • Brownell A, Canales K, Chen Y, Jenkins B, Owen C, Livni E, et al. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 2003; 20: 1064-75.
  • Collingridge DR, Carroll VA, Glaser M, Aboagye EO, Osman S, Hutchinson OC, et al. The Development of [124I]Iodinated-VG76e: A Novel Tracer for Imaging Vascular Endothelial Growth Factor in Vivo Using Positron Emission Tomography. Cancer Res. 2002; 62: 5912-19.
  • Gerhard A, Pavese N, Hotton G, Turkheimer F, Es M, Hammers A, et al. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiology of Disease. 2006; 21: 404-12.
  • Gerhard A, Schwarz J, Myers R, Wise R, Banati R. Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study. NeuroImage. 2005; 24: 591-95.
  • Machado C, Snyder A, Cherry S, Lavenex P, Amaral D. Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: A microPET imaging study. Neuroimage. 2007.
  • Okamura N, Yanai K, Higuchi M, Sakai J, Iwata R, Ido T, et al. Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine. British journal of pharmacology. 2000; 129: 115.
  • Okello A, Edison P, Archer H, Turkheimer F, Kennedy J, Bullock R, et al. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology. 2009; 72: 56.
  • Politis M, Pavese N, Tai Y, Tabrizi S, Barker R, Piccini P. Hypothalamic involvement in Huntington's disease: an in vivo PET study. Brain. 2008; 131: 2860.
  • Royet J, Zald D, Versace R, Costes N, Lavenne F, Koenig O, et al. Emotional responses to pleasant and unpleasant olfactory, visual, and auditory stimuli: a positron emission tomography study. Journal of Neuroscience. 2000; 20: 7752.
  • Rudd J, Warburton E, Fryer T, Jones H, Clark J, Antoun N, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation. 2002; 105: 2708.
  • Sullivan A, Opacka-Juffry J, Hotten G, Pohl J, Blunt S. Growth/differentiation factor 5 protects nigrostriatal dopaminergic neurones in a rat model of Parkinson's disease. Neuroscience letters. 1997; 233: 73-76.
  • Torres E, Fricker R, Hume S, Myers R, Opacka-Juffry J, Ashworth S, et al. Assessment of striatal graft viability in the rat in vivo using a small diameter PET scanner. Neuroreport. 1995; 6: 2017.

SISCOM (Subtraction Ictal SPECT CO-registered to MRI)

  • Bouilleret V, Valenti MP, Hirsch E, Semah F, Namer IJ. Correlation Between PET and SISCOM in Temporal Lobe Epilepsy. J Nucl Med. 2002; 43: 991-98.
  • Brinkmann BH, O'Brien TJ, Aharon S, O'Connor MK, Mullan BP, Hanson DP, et al. Quantitative and clinical analysis of SPECT image registration for epilepsy studies. J Nucl Med. 1999; 40: 1098-105.
  • Brinkmann BH, O'Brien TJ, Mullan BP, O'Connor MK, Robb RA, So EL. Subtraction ictal SPECT coregistered to MRI for seizure focus localization in partial epilepsy. Mayo Clin Proc. 2000; 75: 615-24.
  • Brinkmann BH, O'Brien TJ, Webster DB, Mullan BP, Robins PD, Robb RA. Voxel significance mapping using local image variances in subtraction ictal SPET. Nucl Med Commun. 2000; 21: 545-51.
  • Kaiboriboon K, Bertrand ME, Osman MM, Hogan RE. Quantitative Analysis of Cerebral Blood Flow Patterns in Mesial Temporal Lobe Epilepsy Using Composite SISCOM. Journal of Nuclear Medicine. 2005; 46: 38-43.
  • Kaiboriboon K, Lowe VJ, Chantarujikapong SI, Hogan RE. The usefulness of subtraction ictal SPECT coregistered to MRI in single- and dual-headed SPECT cameras in partial epilepsy. Epilepsia. 2002; 43: 408-14.
  • O'Brien TJ, Brinkmann BH, Mullan BP, So EL, Hauser MF, O'Connor MK, et al. Comparative study of 99mTc-ECD and 99mTc-HMPAO for peri-ictal SPECT: qualitative and quantitative analysis. J Neurol Neurosurg Psychiatry. 1999; 66: 331-9.
  • O'Brien TJ, So EL, Mullan BP, Cascino GD, Hauser MF, Brinkmann BH, et al. Subtraction peri-ictal SPECT is predictive of extratemporal epilepsy surgery outcome. Neurology. 2000; 55: 1668-77.
  • O'Brien TJ, So EL, Mullan BP, Hauser MF, Brinkmann BH, Jack CR, Jr., et al. Subtraction SPECT co-registered to MRI improves postictal SPECT localization of seizure foci. Neurology. 1999; 52: 137-46.
  • Wetjen NM, Cascino GD, Fessler AJ, So EL, Buchhalter JR, Mullan BP, et al. Subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging in evaluating the need for repeated epilepsy surgery. J Neurosurg. 2006; 105: 71-6.

Volumetric Analysis Using Stereology

  • Bae KT, Tao C, Zhu F, Bost JE, Chapman AB, Grantham JJ, et al. MRI-based kidney volume measurements in ADPKD: reliability and effect of gadolinium enhancement. Clinical Journal of the American Society of Nephrology. 2009;4(4):719.
  • Hogan MC, Masyuk TV, Page LJ, Kubly VJ, Bergstralh EJ, Li X, et al. Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver. J Am Soc Nephrol. 2010;21:1052-61.
  • Howard MA, Roberts N, Garcia-Finana M, Cowell PE. Volume estimation of prefrontal cortical subfields using MRI and stereology. Brain Research Protocols. 2003;10(3):125-38.
  • Hussain Z, Roberts N, Whitehouse G, Garcia-Finana M, Percy D. Estimation of breast volume and its variation during the menstrual cycle using MRI and stereology. British Journal of Radiology. 1999;72(855):236.
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Stroke Assessment

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Traumatic Brain Injury Research

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White Matter Lesion Assessment

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Hippocampal Volume References

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